The 1912 Carlisle Indians football team represented the Carlisle Indian Industrial School as an independent during the 1912 college football season.

Led by 11th-year head coach Pop Warner, the Indians compiled a record of 12–1–1 and outscored opponents 454 to 120, leading the nation in scoring.

[1] It featured the Hall of Famers Jim Thorpe, Joe Guyon, and Gus Welch.

Dwight D. Eisenhower was a halfback on the Army team defeated by Carlisle.

The first six-point touchdowns were registered in Carlisle's 50–7 win over Albright College on September 21.