After opening with a 33–0 Wednesday win over Albright, Lehigh beat Delaware 45–0.

Carlisle beat Dickinson 35–0, and followed on Wednesday with a 65–0 win over Villanova at Harrisburg, Pennsylvania.

October 19 Yale won at Army, 16–0, Dartmouth won at Williams 21–0, Harvard beat Amherst 46–0, and Princeton beat Syracuse 62–0 and as all four Ivy teams stayed unbeaten.

Wisconsin beat Purdue 41–0, Michigan won at Ohio State 14–0, and Chicago defeated Iowa 34–14.

Harvard defeated Brown 30–10 and Yale beat Washington & Jefferson, 13–3.

Charles Brickley of Harvard intercepted two passes and kicked a 47–yard field goal and set up a touchdown for Harvard in its 16–6 win [4] Carlisle won its 9th game, staying unbeaten with a 34–14 win over Lehigh.

Georgetown beat North Carolina 37–10 in a game played in Richmond, Virginia.

November 9 In an intersectional meeting between the best teams of the East and the South, Harvard hosted Vanderbilt.

Harvard played all of its substitutes, and scored a touchdown and a field goal in a 9–3 game to give Vandy its only loss of the season.

[5] Carlisle visited West Point, beating Army 27–6, as Jim Thorpe scored three touchdowns and three extra points, and Alex Arcasa scored two more TDs.

[6] Army halfback (and future American president) Dwight D. Eisenhower was injured while tackling Thorpe.

Eisenhower, who was described in the press as someone "who hits the line harder than any other man on the Army team" [7] played his last game the following week against Tufts University.

Texas beat Ole Miss 53–14 in a Wednesday game at Houston.

Wisconsin closed a perfect season with a 28–10 win at Iowa, to finish 7–0–0.

Purdue beat Indiana 34–7 and Chicago won 7–0 over visiting Minnesota.

Lehigh won at Lafayette 10–0 Swarthmore closed its season with a 0–0 tie at Dickinson.

November 28, Thanksgiving Day, Penn State closed its season with a 38–0 win at Pittsburgh, to finish 8–0–0.

Vanderbilt (8–0–1) defeated visiting previously unbeaten Sewanee (5–0–2), winning 16–0.