The team, which did not have an official nickname but was generally known as the Buffeds the previous year, adopted the "Blues" nickname for the 1915 season.

They finished 74–78, good for 6th place in the Federal League, 12 games behind the Chicago Whales.

It would be 105 more years—when the Toronto Blue Jays temporarily moved to Buffalo to play the pandemic-shortened 2020 season and avoid border restrictions—before Buffalo hosted Major League Baseball again.

Infielders Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.

= Batting average; HR = Home runs; RBI = Runs batted in Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts Note: G = Games pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts