The 1915 Sewanee Tigers football team represented Sewanee: The University of the South during the 1915 college football season as a member of the Southern Intercollegiate Athletic Association (SIAA).

The Tigers were led by head coach Harris G. Cope in his seventh season and finished with a record of four wins, three losses, and two ties (4–3–2 overall, 1–2–2 in the SIAA).

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