The 1916 Ole Miss Rebels football team represented the University of Mississippi (Ole Miss) as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1916 college football season.
Led by second-year head coach Fred A. Robins, the Rebels compiled an overall record of 3–6, with a mark of 0–6 in conference play.
Ole Miss played home games at Hemingway Stadium in Oxford, Mississippi.
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