The 1918 Sewanee Tigers football team represented Sewanee: The University of the South during the 1918 college football season as a member of the Southern Intercollegiate Athletic Association (SIAA).

The Tigers were led by head coach Charles Best in his second season and finished with a record of three wins and two losses (3–2 overall, 0–1 in the SIAA).

Zach Curlin played for Fort Oglethorpe.

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