New Hampshire voted for Republican nominee, Senator Warren G. Harding of Ohio, over the Democratic nominee, Governor James M. Cox of Ohio.

Harding ran with Governor Calvin Coolidge of Massachusetts, while Cox ran with Assistant Secretary of the Navy Franklin D. Roosevelt of New York.

His victory in the New England states was helped by the local popularity of his running mate, Calvin Coolidge, a traditional New England Yankee born in the small-town of Plymouth Notch in neighboring Vermont, who had started his political career in neighboring Massachusetts as its governor.

Despite this, New Hampshire would be Cox's second-strongest antebellum free state after Indiana by popular vote percentage and the third-strongest after Indiana and Cox's Ohio in terms of percentage margin.

New Hampshire voted 5.72% more Democratic than the nation at-large – which is the most Democratic relative to the nation that New Hampshire has ever voted since the Republican Party was founded.