Harding's running mate was Governor Calvin Coolidge of Massachusetts, while Cox ran with Assistant Secretary of the Navy Franklin D. Roosevelt of New York.

Harding won New York State with an overwhelming landslide of 64.56% of the vote to Cox's 26.95%, a victory margin of 37.61%.

Harding received over 60% of the vote in the boroughs of Brooklyn, Queens, and Staten Island, and also won majorities in Manhattan and the Bronx.

1920 remains the only election ever in which a Republican presidential candidate has won an absolute majority of the vote in all five boroughs as well as in New York City as a whole.

1920 made Warren G. Harding the first of three presidential candidates of either party who has been able to sweep every county in New York State, the only others being Republican Calvin Coolidge in 1924 and Democrat Lyndon Johnson in 1964.