1921 Chicago Cardinals season

The 1921 Chicago Cardinals season was their second in the American Professional Football Association.

The Cardinals failed to improve on their previous output of 6–2–2, winning only three APFA games.

Although a myth persists that the team billed itself as the "Racine Cardinals", by 1921, the press generally referred to the team as the "Chicago Cardinals" and references to Chris O'Brien's team with the Racine name were few.

The 1921 Chicago Cardinals consisted the following players, with the number of league games played appended in parentheses.

[24] One member of the team, star quarterback Paddy Driscoll, was later inducted into the Professional Football Hall of Fame.