The 1921 LSU Tigers football team represented the University of Louisiana (now known as Louisiana State University or LSU) as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1921 college football season.
Led by second-year head coach Branch Bocock, the Tigers compiled an overall record of 6–1–1, with a mark of 2–1–1 in conference play, finished tied for ninth in the SIAA.
LSU played home games at State Field in Baton Rouge, Louisiana.
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