Significant games included victories over Pittsburgh (6–0), Penn (38–6), and Lehigh (28–6).

However, Lafayette was retroactively named as the co-national champion for 1921 by the Boand System and Parke H. Davis.

Other selectors chose California, Cornell, and Iowa as the 1921 national champion.

[3] Lafayette guard Frank Schwab was a consensus first-team selection on the 1921 All-America college football team.

[4] The team also included fullback George Seasholtz, who went on to play in the National Football League.