The 1921 Memphis Chicks season represented the Memphis Chicks baseball team in the Southern Association and won their third league pennant.

The team played its games at Russwood Park.

[1] The 1921 Chicks were ranked as the 32nd greatest minor league team of all time.

[2] The team's manager was first baseman Spencer Abbott, and the team was led by Cuban pitching ace Oscar Tuero, who led the league in wins.

[3] Andy High had a .321 batting average.