In their seventh season under head coach Knute Rockne, the Fighting Irish compiled a perfect 10–0 record, defeated Stanford in the 1925 Rose Bowl, and outscored opponents by a total of 285 to 54.

[1] The team was led by the legendary backfield known as the "Four Horsemen" consisting of quarterback Harry Stuhldreher, halfbacks Don Miller and Jim Crowley, and fullback Elmer Layden.

[3] Three of the Four Horsemen, Stuhldreher, Crowley, and Layden, were consensus first-team picks on the 1924 All-America college football team.

[4] Other notable players included tackle Joe Bach and center Adam Walsh.

The following chart provides a visual depiction of Notre Dame's lineup during the 1924 season with games started at the position reflected in parentheses.