Led by first-year head coach was Pop Warner, Stanford compiled an overall record of 7–1–1 with a mark of 3–0–1 in conference play, winning the program's first PCC title as co-champions with California.

[10] Stanford returned to Berkeley as the visiting team two weeks later for the Big Game to determine the PCC championship, facing off against defending PCC champion California, who was also undefeated and had won the past five Big Games.

In fact, Stanford had not won a Big Game since 1914, when both teams were still playing rugby instead of football.

Stanford rallied from a 14-point fourth quarter deficit to force a 20–20 tie and win the conference co-championship.

Eight turnovers doomed Stanford to a 27–10 loss to the Irish, which was led by coach Knute Rockne and the backfield known as The Four Horsemen of Notre Dame.