The 1925 Buffalo Bisons season was their sixth in the league.
The team failed to improve on their previous record against league opponents of 6–5, winning one game.
[2] This was the first season since 1917 that star player Tommy Hughitt did not take the field for Buffalo; he had retired at the end of the previous season.
* The Pottsville Maroons were suspended from the league in December, resulting in the Chicago Cardinals being named the NFL champions.
This article relating to an American football season is a stub.