The 1925 Cal Poly Mustangs football team represented California Polytechnic School—now known as California Polytechnic State University, San Luis Obispo—as a member of the California Coast Conference (CCC) during the 1925 college football season.
Led by fifth-year head coach Al Agosti, Cal Poly compiled an overall record of 4–5 with a mark of 0–2 in conference play.
The team outscored its opponents 110 to 81 for the season.
The Mustangs played home games in San Luis Obispo, California.
Cal Poly was a two-year school until 1941.