The school is within the San Luis Coastal Unified School District (SLCUSD), serving primarily students living in San Luis Obispo.

San Luis Obispo High School is part of the CIF Central Section.

[16] The Tigers compete as members of the Central Coast Athletic Association.

Athletic offerings include: cross country, football, volleyball, water polo, cheer, basketball, soccer, wrestling, swimming, baseball, golf, tennis, volleyball, stunt, and track & field.

[17] On October 30, 2023, the hill behind SLO High caught fire, 124 acres before it was contained.