This was law student Harold Sebring's first of three seasons as the head coach of the Florida Gators football team.

The highlights of the season included conference victories over the Wake Forest Demon Deacons, Clemson Tigers, Mississippi A&M Aggies and Washington & Lee Generals.

Captain and halfback Edgar C. Jones set a Florida single-season scoring record (108 points) that lasted until 1969.

[3] Coaches Tom Sebring, A. C. Tipton, Everett Yon, and Herb Bunker were in charge of the first workout.

[8] As coach Sebring recalled, quarterback Edgar C. Jones "held back from calling plays for himself the year before.

"[9] [1] In the opening contest at Fleming Field in Gainesville on October 3 against coach Stanley L. Robinson's Mercer Bears, Florida won 24–0.

In the third quarter, Brown added a field goal, and Cy Williams recovered a Mercer fumble in the endzone.

[20] In the first game of a doubleheader in Gainesville on October 10, the Gators defeated the Florida Southern Moccasins 9–0, using mostly reserves.

Lamar Sarra once scored after blocking a punt, gathering the ball, and running 10 yards to the endzone.

The lone Gator touchdown came after a series of forward passes put them within Tech territory, including one of nearly 20 yards from Edgar C. Jones to Livingston.

[24][25] The Gators practiced at night with whitewashed footballs in preparation for the homecoming contest with the Wake Forest Demon Deacons.

[31] A large crowd was expected in Montgomery for the game against coach Wallace Wade's Alabama Crimson Tide.

[33] The return to the lineup of Tide center Gordon Holmes, injured against Georgia Tech, and the battle between backs Mack Brown and Edgar C. Jones brought intrigue.

[36] For the ninth week of play, the Gators met coach Bernie Bierman's Mississippi Aggies in Tampa on Plant Field and won 12–0.

[39] The annual Thanksgiving game in Jacksonville with coach James DeHart's Washington & Lee Generals was marked by both teams' use of the forward pass and brought the highlight of the season.

[41] The following chart provides a visual depiction of Florida's lineup during the 1925 season with games started at the position reflected in parentheses.