[2] Fort Myers Senior High School offers the International Baccalaureate program, Advanced Placement, Dual Enrollment, Vocational, Honors, and general education classes.

In addition to the educational programs, the school has thirty FHSAA athletic teams for young men and women.

Between 1887 and 1910, high school-aged students in Fort Myers attended classes in a loose configuration of buildings that were neither adequate nor fully accredited.

Colonel Andrew D. Gwynne, a wealthy cotton broker and wholesale grocer from Memphis, Tennessee, was a winter visitor to Fort Myers.

He told his wife that if Fort Myers ever launched a campaign for a new school facility he would gladly donate to take care of part of the expense.

The board members admitted that the current situation embarrassed the community and did not serve its purpose nor meet the children’s needs.

On October 19, 1911, the Andrew D. Gwynne Institute opened its doors as a fully accredited, state-of-the-art school that the entire community was extremely proud of.

It housed 10 rooms, a principal’s office, a library, a spacious 500-seat auditorium, four restrooms, water fountains, and heat by radiation.

As a fitting testimonial of the love that his fellow townspeople felt for him and for the interest that he showed in them, the first official high school in Fort Myers bore his name.

Today, the Andrew D. Gwynne Institute still stands at the corner of Second and Jackson Streets and is used as an annex by the School Board of Lee County.

By 1914, growth demanded that more facilities be created to properly educate Fort Myers high school students.

Serving as principal at this site were: James L. Orr 1921-22, J. Colin English 1923-24, Miss Katherine Moore 1925-30, Howell Watkins 1931-32, Sidney Ellison 1933-35, Charles Whitnel 1936-37, Ellis Greene 1938-41, E.B.

There have been numerous additions including the Edison Learning Center, the science building, the new gymnasium, the library, a new cafeteria, and the Commons Area wing.

Serving as Principal at its current site have been: Ray Tipton 1950, Maurice Coleman 1951, Damon Hutzler 1952-62, Harold Thompson 1963-73, Herbert D. Wiseman 1974-1992, Dr. James Browder 1992-1994, Joni Logan 1994-1999, Dr. James Browder 2000-2003, Richard Shafer 2003-2006, David LaRosa 2006-2018 and Dr. Robert Butz 2018 to current.

In February 2023, assistant coach Alex Carcioppolo used a racial slur in a team group chat and was subsequently fired.

[9][10] After the game, parents alleged racism and prejudice at the Lee County School District board meeting.

[12] Multiple lawsuits were filed, one of which by former Major League Baseball player Michael Tucker whose son was remained on the field during the walkout.

[15][16] Fort Myers Senior High School's resident women's basketball team was awarded their third consecutive state title in 2018.

[17] The same year point Guard, Destanni Henderson, was acknowledged as one of the most promising student-athletes in woman's basketball as well as playing for McDonald's All-American Team.