Nelson finished last out of 22 teams in the Third Division North, with a record of 10 wins, 6 draws and 26 defeats, corresponding to a tally of 26 points.

Due to the departure of Percy Smith to Bury, Nelson did not have a manager installed during the entire season.

The team played inconsistently throughout the campaign from the outset, losing the opening two matches before winning four consecutive games during September 1927.

Outside of league competition, Nelson entered the FA Cup but were knocked out in the First Round following a 0–3 defeat to Bradford Park Avenue at Seedhill.

Forward Jimmy Hampson, the top goalscorer in 1926–27, was sold to Blackpool in October 1927 for a transfer fee of £1,250 and went on to become an England international.