This World Series also marks the beginning of the Cardinals run of dominance in the National League in the early 1930s.
AL Philadelphia Athletics (4) vs. NL St. Louis Cardinals (2) The A's managed only five hits off of Grimes in Game 1, but all were for extra bases and each produced a run in five different innings.
Al Simmons and Mickey Cochrane hit solo home runs for the A's, helping Lefty Grove to a 5–2 win.
The A's struck first in the bottom of the second when Jimmie Foxx tripled and scored on Bing Miller's sacrifice fly.
The Cardinals loaded the bases in the third on three straight leadoff singles, then Taylor Douthit's lineout and Sparky Adams's sacrifice fly scored a run each.
In the seventh, Bill Shores allowed three consecutive leadoff singles, the last of which by Jimmie Wilson scoring two runs.
Next inning, the Cardinals added another run off of Jack Quinn on back-to-back one-out doubles by Jim Bottomley and Chick Hafey.
In the top of the ninth, Grimes walked Mickey Cochrane and then coughed up a home run ball to Jimmie Foxx.
Earnshaw earned his second win on just one day of rest, pitching a five-hitter; it would be 88 years before another pitcher would start consecutive games in the postseason.
The A's added to their lead next inning when Jimmie Foxx hit a leadoff double, moved to third on a bunt groundout and scored on Mule Haas's sacrifice fly.