[2][3] The first official MLB All-Star exhibition game on July 6, 1933, was held at Comiskey Park (1910–1990) and was part of the 1933 Chicago World's Fair during the city's centennial.

The proceeds ($45,000, net gate receipts) from the game went to a charity for disabled and needy major league players.

Ruth was greeted at home plate by the AL/Chicago White Sox batboy John McBride and teammate Lou Gehrig.

Twenty of the game's thirty-six All-Stars including Ruth would later be inducted into the National Baseball Hall of Fame at Cooperstown, New York.

Two batters later, the game's winning pitcher Lefty Gomez, singled home Dykes for the AL's first run.

In the bottom of the third, after a walk to Charlie Gehringer, Babe Ruth famously hit the first home run in All-Star Game history, putting the AL up 3–0.

Hallahan was chased from the game after walking Lou Gehrig immediately afterward, and was replaced by Lon Warneke.

With Frisch on first with two outs, Hafey lined a shot to right field that looked like it could be a home run, but Ruth reached over the wall to catch it, denying the NL a chance to tie the game.