On Friday, September 20, 1935, the Lions opened their season with a 35–0 victory over the Philadelphia Eagles before a crowd of approximately 10,000 at University of Detroit Stadium.
[3] Following the game, the Associated Press reported that the Lions has "definitely established themselves as serious contenders for the 1935 National Professional football league championship.
"[2] On September 29, 1935, in the second game of the season, the Lions and Chicago Cardinals played to a 10–10 tie in front of approximately 10,000 spectators at the University of Detroit Stadium.
The Lions trailed 3-0 at halftime but scored a touchdown in the third quarter on a 15-yard pass from Dutch Clark to John Schneller.
The Lions then tied the score in the final minutes, as Glenn Presnell kicked a field goal.
[7] In week five, the Lions suffered their second loss of the season, falling to the Green Bay Packers 13–9 at State Fair Park in Milwaukee.
[8] Through the first five games, Ernie Caddel was tied with Dale Burnett for the NFL scoring lead with five touchdowns and 30 points.
The second half was played in heavy fog, "at times almost completely blotting out all action, and making necessary the use of a white ball.
[10] In week seven, the Lions narrowly defeated the Chicago Cardinals in the rain and mud at Wrigley Field.
The final score was 7–6 with the difference being a successful extra point kicked by Dutch Clark after a 12-yard touchdown run by Ernie Caddel in the first quarter.
The Bears scored a safety after Buddy Parker fumbled and recovered the ball behind his own goal line.
The Lions scored again after Christensen intercepted a pass thrown by New York's Ed Danowski and ran it back to midfield.
In the fourth quarter, the Lions blocked a punt, and George Christensen recovered the ball on the Giants' 22-yard line.