The 1941–42 Segunda División season saw 24 teams participate in the second flight Spanish league.
Betis and Zaragoza was promoted to Primera División.
Real Unión, Levante and Cartagena were relegated to Divisiones Regionales de Fútbol.
24 teams joined the league, including two relegated from the 1940–41 La Liga and 5 promoted from Divisiones Regionales.