Duquesne finished undefeated, with a record of 8–0, and was ranked eighth in the final AP Poll.
[1][2] They secured their perfect season by beating previously-undefeated Mississippi State in a rematch of the 1937 Orange Bowl.
Steve Sinko took over as Duquesne's acting head coach after Donelli's resignation.
[5][6] Duquesne's John Rokisky was selected by the Associated Press a first-team end on the 1941 All-Eastern football team.
[7] Duquesne finished the season with a share of the 1941 national championship, as later determined by the Massey Ratings.