The 1941 Niagara Purple Eagles football team was represented Niagara University as a member of the Western New York Little Three Conference (Little Three) during the 1941 college football season.
Led by Joe Bach in his fifth and final season, the Purple Eagles compiled an overall record of 2–5–1 record with a mark of 1–1 in conference play, sharing the Little Three title with Canisius and St. Bonaventure [8]