Led by second-year head coach James J. Yeager, the Buffaloes compiled an overall record of 7–2 with a mark of 5–1 in conference play, sharing the MSC title with Utah.

60 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.

[1] [3][4][5] The following Buffalo was selected in the 1943 NFL draft following the season.

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