The 1946 South Dakota Coyotes football team was an American football team that represented the University of South Dakota as a member of the North Central Conference (NCC) during the 1946 college football season.
In their ninth season under head coach Harry Gamage, the Coyotes compiled a 2–4 record (1–2 against NCC opponents), finished in sixth place out of seven teams in the NCC, and were outscored by a total of 106 to 38.
[1] They played their home games at Inman Field in Vermillion, South Dakota.