In their third, non-consecutive season under head coach Dave Stephens, the team compiled a 9–3 record, won the OCC championship, and outscored opponents by a total of 193 to 92.
[4] Four Southeastern players were selected by the Associated Press as first-team players on the 1946 All-Oklahoma Collegiate Conference team: Gene Jones at end; James Harris at guard; Lloyd "Red" Skelton at center; and Howard Guyer at quarterback.
In addition, end Bill Caldwell and fullback Lee Allen were named to the second team.
Tackle Bert Lana and guard Charles Hollingsworth were named to the third team.
[5] The team played its home games at Paul Laird Field in Durant, Oklahoma.