The 1948 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as a member of the Gulf States Conference during the 1948 college football season.
In their ninth year under head coach Reed Green, the team compiled a 7–3 record.
Mississippi Southern was ranked at No.
108 in the final Litkenhous Difference by Score System ratings for 1948.
This college football 1940s season article is a stub.