Forty-six school and/or national records were broken with freshman quarterback Martin Hankins setting 21 new standards.

Before a packed house on a rainy night, Southeastern opened its first season in 18 years rallying to defeat Arkansas-Monticello, 22–17, as Hankins hit Choni Francis on a 22-yard scoring pass with 6:49 remaining in the game.

They finished with a perfect 7–0 record in conference play and earned their first-ever trip to the NCAA Division 1 playoffs.

In the second round, the SLU faced Sam Houston State in a rematch of the regular-season game played between the two in which Southeastern won 34–21.

[3] After posting a 7–4 regular-season record in 2019 the lions earned the program's third playoff berth, hosting 10th ranked Villanova in the first round.

After trailing 31–14 at halftime, Southeastern came back to upset the wildcats 45–44, led by quarterback Chason Virgil's 474 yards passing.

[6] Louisiana leads the series 21–17–3 with the last game played in 2022. Notable alumni include: Announced non-conference opponents as of February 4, 2025.