Detroit outscored its opponents by a combined total of 226 to 143 and finished with a 6–3–1 record in its sixth year under head coach Chuck Baer.
Two Titans were selected as first-team players on the 1950 All-Missouri Valley Conference football team: guards Alex Smail and Ed Wood.
[4] Dutch Clark, later inducted into both the Pro and College Football Halls of Fame, joined the Titans' staff as backfield coach in 1950.
[4] In late December 1950, Chuck Baer resigned as the Titans' head football coach, citing "personal reasons".
Celestin J. Steiner, appointed a committee to investigate and make recommendations about the university's entire athletic program.