Notable alumni include political and business leaders such as U.S. senator Gary Peters and former Ford COO Jim Padilla, both from the University of Detroit.

Since the merger, the university has produced the likes of actor Keegan-Michael Key and news anchor Allison Payne.

The campus is home to the School of Law in downtown Detroit at 651 East Jefferson (across from the Renaissance Center).

This campus, located at 41555 West 12 Mile Road, serves as a dedicated educational hub for nursing students and also houses the Detroit Mercy Eye Institute.Detroit Mercy's most popular undergraduate majors, in terms of 2021 graduates were Registered Nursing/Registered Nurse, Biology/Biological Sciences, Business Administration & Management, Architectural and Building Sciences, Dental Hygiene/Hygienist, Mechanical Engineering.

[13] The Black Abolitionist Archive is a digital collection of over 800 speeches by antebellum African Americans including 14,000 documents, an extensive microfilm library, a clipping file, a library of scholarly books, articles, and dissertations providing a portrait of black involvement in the anti-slavery movement.

[14] Dr. James O. Horton of the Smithsonian Institution’s Afro-American Communities Project has called it “the most extensive primary source collection on antebellum black activism.”[14] The Padre Guadalupe Carney Latin American Solidarity Archive (CLASA) contains a collection of Spanish and English books, human rights reports, independent newspapers and newsletters, and social justice papers representing more than 25 years of work by individuals and organizations working in solidarity to aid the people of Latin America.

The center's main service is the CSE Boost Program, which is an in-person workshop for early-stage social organizations.

[18] The Institute for North Korean Studies (INKS) is a United States–based non-partisan, non-proprietary research center founded at the College of Business Administration at the University of Detroit Mercy in April 2004.

INKS is distinguished as the first research center in the United States or Europe to focus exclusively on North Korea.

[23] Detroit Mercy Law students must take one regular, semester-long "clinic" course that places them in contact with the underrepresented in an area of their choice, with options covering most specializations.

The courses provide them with the skills and knowledge requisite for their clinical work, together with guided reflection and individual contact with the professor, including a comprehensive final interview.

[39] Fraternities and sororities (in alphabetical order) The University of Detroit Mercy sponsors 17 NCAA Division I-level varsity sports teams.

Men's and women's Detroit Mercy Titans teams compete in each sport in the Horizon League.

An Inkster, Michigan native, Montgomery was an assistant coach at UDM for the end of the 2020-21 season, in which time the Titans went 11-3 down the stretch.

[42] McCallum's predecessor, Perry Watson, led a successful program at Detroit's Southwestern High School before coming to Detroit Mercy after some years as an assistant coach at the University of Michigan and maintained strong recruiting ties within the city's public league.

[46] In his final year as a college head coach in 1977, Vitale led the Titans to a school record 25 victories and the Round of 16 in the 1977 NCAA tournament before losing to Michigan, 86–81.

[45] Vitale went on to coach the Detroit Pistons before beginning his broadcasting career with ESPN in 1979 and was the color commentator for the first college basketball game carried by the new network.

As its lead college basketball analyst, he helped make the network an integral part of the game's popularity.

[48] Highlights from the Detroit Mercy Titans men's and women's basketball teams include appearances in the 2011–12 postseason.

The men's basketball team captured the 2011-12 Horizon League Championship and reached the NCAA Tournament for the sixth time in its history and first since 1999.