The 1950 South Dakota Coyotes football team was an American football team that represented the University of South Dakota as a member of the North Central Conference (NCC) during the 1950 college football season.
In their 12th season under head coach Harry Gamage, the Coyotes compiled a 4–5 record (3–3 against NCC opponents), finished in fifth place out of seven teams in the NCC, and were outscored by a total of 230 to 201.
[1] They played their home games at Inman Field in Vermillion, South Dakota.