The tournament was organized in a single table for the first time.
The league was organized into a single division of 18 teams.
Each team played a total of 34 matches (17 at home, 17 away).
At the end of the 34th round, teams at the first two positions of the classification were promoted in Serie B for the 1953–54 season.
On the contrary, teams which finished their league at the last four places were relegated in IV Serie.