Incumbent Democratic Congressman L. Mendel Rivers of the 1st congressional district, in office since 1941, was unopposed in his bid for re-election.

Incumbent Democratic Congressman John J. Riley of the 2nd congressional district, in office since 1951, was unopposed in his bid for re-election.

Bryan Dorn of the 3rd congressional district, in office since 1951, defeated Republican challenger David Dows.

Incumbent Democratic Congressman Joseph R. Bryson of the 4th congressional district, in office since 1939, was unopposed in his bid for re-election.

Incumbent Democratic Congressman John L. McMillan of the 6th congressional district, in office since 1939, was unopposed in his bid for re-election.