The 1957–58 season of Alessandria Unione Sportiva's was their 46th in Italian football and their 11th in Serie A.

Back in Serie A after 9 years, Alessandria U.S. built a competitive team, comprehensive of Italy defender Giacomazzi, talented Tagnin and Switzerland forward Vonlanthen.

[1] Alessandria's coaches Robotti and Pedroni settled the team with a strong "catenaccio":[2] the quality of the holding midfielder-line granted good matches, and for a long time the Grigi's occupied the first positions of the classification, even if they fell away in the last part of the championship, ending 12th.

[3] In 1957–58 season Alessandria ended as the 3rd best defense in Serie A, with 42 goals against in 34 matches: only Internazionale and Fiorentina did it better.

Roger Vonlanthen, even though he scored only 8 goals (less than the expected), was the top goalscorer.