Bob Howe and Lorraine Coghlan were the defending champions, but Coghlan did not compete.

Howe partnered with Sally Moore but lost in the quarterfinals to Bob Mark and Jeanne Arth.

Rod Laver and Darlene Hard defeated Neale Fraser and Maria Bueno in the final, 6–4, 6–3 to win the mixed doubles tennis title at the 1959 Wimbledon Championships.

[1] Click on the seed number of a player to go to their draw section.