A constitutional referendum was held in Ghana on 27 April 1960.

The main issue was a change in the country's status from a constitutional monarchy with Elizabeth II as head of state, to a republic with a presidential system of government.

Presidential elections were held alongside the referendum, which were won by the incumbent Prime Minister, Kwame Nkrumah.

He was inaugurated on 1 July 1960, replacing Queen Elizabeth II as head of state, and thus eliminating the post of Governor-General.

Four years later another referendum strengthened the president's powers and turned the country into a one-party state (with an official result of 99.91% in support).