The Pirates had two – Dick Groat (1960) and Roberto Clemente (1966) – while the Yankees had five: Yogi Berra (1951, 1954, 1955), Bobby Shantz (1952), Mickey Mantle (1956, 1957, 1962), Roger Maris (1960, 1961), and Elston Howard (1963).

In the top of the first inning, New York right fielder Roger Maris, the eventual 1960 AL MVP, drilled a home run off Law to give the Yankees a 1–0 lead.

Pittsburgh added an insurance run in the sixth when Mazeroski doubled with one out and scored on Virdon's double off Duke Maas, and although the Yankees cut the lead in half on a ninth-inning 2-run home run to right field by Elston Howard, reliever Roy Face successfully closed it out to give the Pirates a 6–4 victory and a 1–0 series lead.

Elston Howard hit a lead-off triple and scored on Bobby Richardson's double to chase Green from the game.

Red Witt relieved Labine and allowed back-to-back RBI singles to Howard and Richardson that made it 12–1 Yankees.

Mantle continued the onslaught by blasting a three-run home run in the seventh off Joe Gibbon and scoring on a wild pitch by Tom Cheney in the ninth after walking and moving to third on a double, making it 16–1 Yankees.

Although the Pirates tacked on two runs in the bottom half of the frame on back-to-back RBI singles by Gino Cimoli and Smoky Burgess, Bobby Shantz relieved Turley and got Don Hoak to hit into the game-ending double play.

The Pirates had seen their pitching fail them in the last two games, as the team fell victim to the powerful Yankee bats.

The game was scoreless until the bottom of the fourth, when Bill Skowron launched a home run off Law to give New York a 1–0 advantage.

The very next half-inning, though, Pittsburgh stormed back, when with two on and two outs, Law doubled in Gino Cimoli to tie the game and Bill Virdon's two-run single put the Pirates up 3–1.

With the series now tied at two, Yankee manager Casey Stengel started pitcher Art Ditmar, his Game 1 starter (in which he was ineffective), against the Pirates' Harvey Haddix, who had become famous for taking a perfect game into the thirteenth inning in a loss to the Milwaukee Braves the previous year.

Dick Stuart singled and was forced out at second on a fielder's choice hit by Gino Cimoli, who then moved to third on a double by Smoky Burgess.

After this offensive outburst, Stengel yanked Ditmar and replaced him with Luis Arroyo, who finally ended the inning and stranded Mazeroski.

The next half-inning, New York picked up a run when Elston Howard doubled, moved to third on a ground-out by Bobby Richardson, and scored on another grounder by Kubek.

However, the Pirates extended their lead back to three runs in the third, when Roberto Clemente singled home Groat, who led off with a double.

After a Yogi Berra walk and a Bill Skowron single, Elston Howard was hit by a pitch to load the bases (Eli Grba ran for him).

Ford himself then notched the first RBI of the game, with a ground ball single to his counterpart Friend that scored Berra.

The next inning, after a lead-off hit-by-pitch and double, Mantle cracked a two-run single that scored Tony Kubek and Roger Maris.

After a Yogi Berra single moved Mantle to third, Pirates skipper Danny Murtaugh removed the clearly ineffective Friend in favor of Tom Cheney.

After retiring the first two batters, Turley walked Bob Skinner, then first baseman Rocky Nelson homered, Pittsburgh's first home run since Bill Mazeroski's in Game 1, to give the Pirates a 2–0 lead.

Gino Cimoli (pinch-hitting for Face) led off with a single, and Virdon hit a ground ball to short for what could have been a double play.

Hal Smith, who had replaced Smoky Burgess at catcher after being pinch-ran for by Joe Christopher followed with a three-run home run to give the Pirates a 9–7 lead.

Bobby Richardson and pinch-hitter Dale Long both greeted him with singles, and Pirates manager Danny Murtaugh was forced to remove the veteran pitcher in favor of Harvey Haddix.

With a count of one ball and no strikes, the Pirates' second baseman smashed a historic long drive over the left field wall for his second home run of the Series (left fielder Berra had no chance to catch it despite following it to the wall), winning the game 10–9 and crowning the Pirates as World Series champions.

Years later, Mickey Mantle was quoted in Ken Burns' documentary Baseball as saying that losing the 1960 series was the only loss, amateur or professional, he cried actual tears over.

For Bill Mazeroski, by contrast, his Series-clinching home run was the highlight of a Hall of Fame career otherwise notable mostly for excellent defense.

The lone exception is a black-and-white kinescope of the entire telecast of Game 7, which was discovered in a wine cellar in Bing Crosby's former home in Hillsborough, California, in December 2009.

[13][14] The NBC television announcers for the Series were Bob Prince and Mel Allen, the primary play-by-play voices for the Pirates and Yankees respectively.

[13] On October 13, 2010, for the 50th anniversary of the series winning home run, a gala was hosted by the Byham Theater in downtown Pittsburgh, where the historic telecast of Game 7 was re-aired in its entirety.

Bill Virdon, 1960 MVP Dick Groat and Yankee Bobby Richardson were guest speakers, with actor and Pittsburgh native Jeff Goldblum hosting the event.