The 1961 Southern 500 was a race that took place at Darlington Raceway on 4 September 1961, in the NASCAR Grand National Series.

Nelson Stacy won after 364 laps, after taking the lead from Fireball Roberts late in the race.

Among the 43 competitors in the 1961 Southern 500, Marvin Potter, Paul Lewis and Woodie Wilson were involved in a crash, resulting in them coming 32nd, 33rd and 34th respectively.

[7] Tiny Lund crashed toward the end of the race, finishing in 15th position.

[8] Prior to the commencement of the race, South Carolina Senator Strom Thurmond was present to give a political speech in which he claimed that South Carolina would secede from the United States because of its opposition to civil rights legislation.