Johnson ran with Senator Hubert H. Humphrey of Minnesota, while Goldwater's running mate was Congressman William E. Miller of New York.

Johnson carried Massachusetts in a landslide, taking 76.19% of the vote to Goldwater's 23.44%, a Democratic victory margin of 52.75%.

The staunch conservative Barry Goldwater was widely seen in the liberal Northeastern United States as a right-wing extremist;[3] he had voted against the Civil Rights Act of 1964, and the Johnson campaign portrayed him as a warmonger who as president would provoke a nuclear war.

[3] Consequently, the incumbent Johnson was able to sweep the state—and indeed Goldwater wrote off this state and neighboring Connecticut, Rhode Island, and New York, as well as New Jersey, Pennsylvania and Michigan, from the beginning of his presidential campaign, prior to Kennedy's assassination.

[8] In Suffolk County, home to the state's capital and largest city, Boston, Johnson took 86.2% of the vote.