Incumbent President Lyndon B. Johnson of Texas, the Democratic Party candidate, won Oklahoma with an 11.49 percent margin of victory against Senator Barry Goldwater of Arizona, winning its eight electoral votes.

In 1964, a majority of voters rejected the staunchly conservative Goldwater, who was portrayed as a right-wing extremist, and defected to the more moderate Johnson.

In typical fashion for the time, Johnson overwhelmingly won Southern Oklahoma, the most Democratic region of the state, carrying every county with over 60% of the vote.

Goldwater performed strongly in the northern region including the Oklahoma Panhandle and Garfield County, home to Enid.

Johnson's strong performance likely helped fellow Democrat Fred R. Harris down-ballot in his narrow victory in the concurrent special election to the United States Senate.