The 1965 Mexican Grand Prix was a Formula One motor race held at Ciudad Deportiva Magdalena Mixhuca in Mexico City on October 24, 1965.

The Brabham-Climax of Dan Gurney finished the race second and the Lotus-Climax of Mike Spence completed the podium.

Honda's testing proved to be of benefit as Jim Clark and Graham Hill dropped out with engine problems and Jackie Stewart retired with clutch problems to leave Dan Gurney as the only challenger to Richie Ginther.

Lorenzo Bandini and Pedro Rodríguez collided at the hairpin, leaving Ginther to stroll home for Honda's first, and his only, Grand Prix win.

Gurney and Mike Spence took the other podium places, with Jo Siffert, Ronnie Bucknum and Richard Attwood completing the points scorers.