The 49th Tour of Flanders cycling classic was held on Saturday, 17 April 1965.

The race was won by Dutch rider Jo de Roo in a two-man sprint with Edward Sels.

[1] 51 of 119 riders finished.

[2] The race started in Ghent and finished in Gentbrugge – covering 240 km.

This Tour of Flanders race article is a stub.