The 1966 East Texas State Lions football team represented East Texas State University in the 1966 NAIA football season.
They were led by head coach Ernest Hawkins, who was in his third season at East Texas State.
The Lions played their home games at Memorial Stadium and were members of the Lone Star Conference.
With a 5–3–2 record, the Lions won the Lone Star Conference championship, the first of four under Hawkins.
Tailback Curtis Guyton was named All-American, the first black player in program history to be named All-American.