The Lone Star Conference (LSC) is a college athletic conference affiliated with the National Collegiate Athletic Association (NCAA) at the Division II level.

Member institutions are located in the South Central states, with schools in Texas, Oklahoma, and New Mexico, with two members in the Pacific Northwest states of Oregon and Washington competing as affiliates for football only.

The conference was formed in 1931 when five schools withdrew from the old Texas Intercollegiate Athletic Association.

In 2016, 4 schools (Eastern New Mexico, Midwestern State, UT-Permian Basin, and West Texas A&M) joined the Heartland as affiliate members for Men's soccer.

This format ended after the 2015 season due to the addition of Western New Mexico, UT Permian Basin, and Oklahoma Panhandle State.