The 1968 Sainte-Marie Douglas DC-6 crash was an aviation accident that occurred on the island of La Réunion, a French overseas department in the southwestern Indian Ocean, on the evening of 9.

A military Douglas DC-6 aircraft taking off from Gillot Airport at 23h 15'  crashed two minutes later in the commune of Sainte-Marie, Réunion, resulting in the deaths of sixteen people, including French General Charles Ailleret [fr].

This aviation accident remains the deadliest in the history of La Réunion.

Departing from Gillot at 23:00, the plane, which was originally scheduled to land in Djibouti at 11:40, crashed 55 seconds after takeoff.

[1] The only survivor was General Ailleret's nurse, and the accident remains classified as defense secret and unsolved to this day: sabotage, alcohol, or suicide action.