Spiro is a town in Le Flore County, Oklahoma, United States.

It is part of the Fort Smith, Arkansas-Oklahoma Metropolitan Statistical Area.

[4] Developed as a railroad station in an agricultural area in the late 19th century, the small town is notable for its proximity to the Spiro Mounds.

It is the westernmost site of the expansive Mississippian culture, which had associated centers through the Mississippi and tributary river valleys.

[5] A post office was established at Spiro, Indian Territory on September 21, 1898.

[6] At the time of its founding, Spiro was located in Skullyville County, a part of the Moshulatubbee District of the Choctaw Nation.

Another claims it was the maiden name of the mother of a Fort Smith banker.

[5] On March 26, 1976, the town was struck by an F5 tornado, the highest level on the Fujita scale, resulting in two deaths.

Doug Harper, a lifelong resident of and business owner in Spiro, serves as the towns mayor.