The 1980–81 Scottish Inter-District Championship was a rugby union competition for Scotland's district teams.

[1] This season saw the 28th Scottish Inter-District Championship.

South won the competition with 3 wins.

Durham County: Connacht:

Glasgow District: Irish Army:

South of Scotland District: Leinster:

North and Midlands: Mid District:

North and Midlands: Mid District:

North and Midlands: South of Scotland District: